Japanese

Title	周期性嘔吐症候群の発作期におけるアトロピン硫酸塩の有効性
Subtitle	原著
Authors	一木美穂, 近藤宏樹, 井上智弘, 南方俊祐, 舩戸契, 虫明聡太郎
Authors (kana)
Organization	近畿大学奈良病院 小児科
Journal	日本小児栄養消化器肝臓学会雑誌
Volume	35
Number	2
Page	63-69
Year/Month	2021 /
Article	原著
Publisher	日本小児栄養消化器肝臓学会
Abstract	「要旨」周期性嘔吐症候群 (CVS) の治療目標は, 1) 発作間欠期間の延長, 2) 発作期間の短縮, および3) 発作症状の軽減にある. 1) に対しては複数の薬剤の有効性が報告されているが, 2, 3) に対する薬剤の有効性を示した報告はない. 今回, 当科で診療中のCVS10症例に対して, 発作初期にアトロピン硫酸塩の静注, または経口・経腸投与を行い, 本人または保護者への質問票により効果の有無を評価した. 静注は9例中8例で, 経口・経胃瘻投与は10例中9例で有効であった. 5例では発作期間の短縮, または発作回避が可能なときがあった. 有効例における効果持続はいずれも5〜6時間以下であった. CVSにおける唾液・胃液の分泌亢進と胃の蠕動亢進, 痙性腹痛は, コリン作動神経の過剰興奮を背景とする. アトロピン硫酸塩は短時間ながら明確にこれを抑制し, 発作初期の症状の軽減及び発作回避に有用であると考えられた.
Practice	臨床医学：内科系
Keywords	周期性嘔吐症候群, 発作期, アトロピン硫酸塩

English

Title	Atropine sulfate is effective for attacks of cyclic vomiting syndrome
Subtitle
Authors	Miho Ichiki, Hiroki Kondou, Tomohiro Inoue, Shunsuke Minakata, Kei Funato, Sotaro Mushiake
Authors (kana)
Organization	Department of pediatrics, Kindai university Nara Hospital
Journal	Japanese Journal of Pediatric Gastroenterology, Hepatology and Nutrition
Volume	35
Number	2
Page	63-69
Year/Month	2021 /
Article	Original article
Publisher	The Japanese Society for Pediatric Gastroenterology, Hepatology and Nutrition
Abstract	The goals for treatment of cyclic vomiting syndrome (CVS) are prolongation of intermittent attack period, shortening of attack duration or termination, and reduction of attack symptoms. The effectiveness of multiple drugs has been reported for prolongation of intermittent attack period, but there are few reports of treatments that can reduce symptoms or terminate each attack. Ten CVS patients undergoing medical care at our department were treated with administration of atropine sulfate (AS) intravenously, orally or enterally at the initiation of attack. The effectiveness was evaluated by a questionnaire to the patients or parents. Intravenous administration was effective in 8 of 10 cases. Oral and enteral administration were also effective in 9 out of 10 cases. In 5 cases, the attack period was shortened or progression of attacks were sometimes avoided. In all the effective cases, the effect duration was 5 to 6 hours or less. Gastrointestinal symptoms in CVS are salivary and gastric juice secretion, increased gastric peristalsis, and spastic abdominal pain, with a background of hyperexcitation of cholinergic nerves. AS was clearly effective in suppressing these events in a short time. Administration of AS in the early phase of CVS attacks was thought to be useful in reducing symptoms and avoiding the progression of attacks.
Practice	Clinical internal medicine
Keywords

• 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。

参考文献