Japanese

Title	多彩な病態を示す好酸球性消化管疾患の4例
Subtitle	第109回 日本消化器内視鏡学会関東支部例会論文集 B論文 原著
Authors	櫻井洋一1)5), 鈴木弘文2), 阿部径和3), 岡屋智久1), 菅野勇4), 山崎一人4), 渡邉和義5)
Authors (kana)
Organization	1)千葉県済生会習志野病院 外科, 2)千葉県済生会習志野病院 健診科, 3)千葉県済生会習志野病院 消化器科, 4)千葉県済生会習志野病院 病理科, 5)天王台消化器病院 消化器外科
Journal	Progress of Digestive Endoscopy（2001年から）
Volume	96
Number	1
Page	64-66
Year/Month	2020 /
Article	原著
Publisher	日本消化器内視鏡学会関東支部会
Abstract	「はじめに」好酸球性消化管疾患(eosinophilic gastrointestinal diseases, 以下EGIDs)は食道運動障害などの症状を起こす慢性アレルギー疾患である. 欧米では急速に罹患率が上昇しているとされる. 本邦でも2006年に初めて報告されて以来, 認知度の高まりとともに増加している. GERDとして長期的に経過観察され生検を行っていない症例など的確な診断がされていない症例も多く存在する. そこで最近経験した好酸球性消化管疾患4例の臨床所見・内視鏡所見・併存疾患などにつき検討したので報告する. 「症例」今回経験した好酸球性消化管疾患4例の臨床的背景・所見をTable 1に示した. 好酸球性胃腸炎(eosinophilic gastroenteritis, 以下EGE)1例, 好酸球性食道炎(EoE)3例で, 男性3例, 女性1例, 平均年齢は46±7歳であった. 症例1は, 小児期よりアトピー性皮膚炎を認め, 健診にて末梢血の好酸球増多を指摘された.
Practice	臨床医学：内科系
Keywords	好酸球性消化管疾患, 好酸球性食道炎, セリアック病

English

Title	Eosinophilic gastrointestinal diseases showing a variety of clinical manifestations
Subtitle
Authors	Yoichi Sakurai1)5), Hirofumi Suzuki2), Michikazu Abe3), Tomohisa Okaya1), Isamu Sugano4), Kazuhito Yamazaki4), Kazuyoshi Watanabe5)
Authors (kana)
Organization	1)Department of Surgery, Chiba-ken Saiseikai Narashino Hospital, 2)Department of Medical Examination, Chiba-ken Saiseikai Narashino Hospital, 3)Department of Gastroenterology, Chiba-ken Saiseikai Narashino Hospital, 4)Department of Pathology, Chiba-ken Saiseikai Narashino Hospital, 5)Department of Gastrointestinal Surgery, Tennohdai Digestive Hospital
Journal	Progress of Digestive Endoscopy
Volume	96
Number	1
Page	64-66
Year/Month	2020 /
Article	Original article
Publisher	Japan Gastroenterological Endoscopy Society Kanto Chapter
Abstract	Eosinophilic gastrointestinal diseases (EGIDs) are distinct immunologic diseases that show a variety of clinical manifestations and endoscopic findings with unknown cause or association of immunologic diseases. The incidence of eosinophilic esophagitis (EoE) seems to be increasing, although it is still unclear whether this is general phenomenon or attributable to an increased awareness of the disease. Our aim was to examine clinical features, endoscopic findings, and associated diseases of 4 cases of EGIDs. These cases included 1 eosinophilic gastroenteritis and 4 EoE, 3 men and 1 woman, and the mean age was 46 +- 7 year-old. The most common endoscopic findings were mucosal edema, linear furrows, and rings in esophagus, and white specks in colon. An increased number of eosinophils was infiltrated in esophageal or colonic epithelium. Two cases were complicated with celiac disease (CD), and scleroderma, respectively and all cases were associated with gastroesophageal reflux disease. While one case complicated with CD showed a marked serum eosinophilia, others were in normal serum eosinophils. Three cases were treated with a proton-pump inhibitor and the symptoms improved in 2 cases.
Practice	Clinical internal medicine
Keywords

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