アブストラクト
Japanese
Title | 抗がん剤変更時における高齢消化器がん患者のフレイルとQOLの関連 |
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Subtitle | 原著 |
Authors | 大日方裕紀1), 矢ヶ崎香2), 浜本康夫3), 平田賢郎3), 須河恭敬4), 小松浩子5) |
Authors (kana) | |
Organization | 1)国際医療福祉大学看護学部, 2)慶應義塾大学看護医療学部, 3)慶應義塾大学医学部腫瘍センター, 4)東京医療センター臨床腫瘍科, 5)日本赤十字九州国際看護大学 |
Journal | 日本看護科学会誌 |
Volume | 42 |
Number | |
Page | 254-262 |
Year/Month | 2022 / |
Article | 原著 |
Publisher | 日本看護科学学会 |
Abstract | 「要旨」目的: 抗がん剤変更時における高齢消化器がん患者のフレイルの実態とQOLの関連を明らかにすることである. 方法: 抗がん剤変更時の65歳以上の消化器がん患者を対象に横断的観察研究を行った. フレイル及びQOLの測定は, G8とEQ-5D-5Lを用いた. 結果: 51名が研究参加を同意し, データ収集と分析を行った. フレイルに該当する高齢消化器がん患者は, 40名(78.4%)であった. フレイルには, BMI(p < .001), 下腿三頭筋周囲径(p = .023)が関連していた. また, フレイル群は非フレイル群に比べQOLが低かった(p = .04). 結論: 抗がん剤変更時における高齢消化器がんのフレイル患者の特徴とフレイルサイクルへ陥りやすい集団が明らかになった. 治療変更時における高齢がん患者に対するフレイルの評価は, QOLを考慮した個別的な支援の重要な要素になり得る. |
Practice | 看護学 |
Keywords | 抗がん剤変更時, 高齢がん患者, フレイル, Quality of Life, Chemotherapy, Older cancer patient, Frailty |
English
Title | The Relationship between Frailty and Quality of Life in Older Digestive Cancer Patients when Choosing an Anticancer Drug Regimen |
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Subtitle | |
Authors | Hironori Ohinata1), Kaori Yagasaki2), Yasuo Hamamoto3), Kenro Hirata3), Yasutaka Sukawa4), Hiroko Komatsu5) |
Authors (kana) | |
Organization | 1)Department of Nursing, International University of Health and Welfare, 2)Faculty of Nursing and Medical Care, Keio University, 3)Keio Cancer Center, Keio University School of Medicine, 4)Department of Clinical Oncology, Tokyo Medical Center, 5)Japanese Red Cross Kyushu International College of Nursing |
Journal | Journal of Japan Academy of Nursing Science |
Volume | 42 |
Number | |
Page | 254-262 |
Year/Month | 2022 / |
Article | Original article |
Publisher | Japan Academy of Nursing Science |
Abstract | [Abstract] Aim: The study aimed to investigate the relationship between frailty and quality of life (QOL) in older patients with gastrointestinal cancer at the time when an anticancer drug regimen is changed. Methods: We conducted a cross-sectional observational study of gastrointestinal cancer patients aged 65 years or older at the time of anticancer drug change. Frailty and QOL were measured using G8 and EQ-5D-5L. Results: Fifty-one patients agreed to participate in this study. Data collection and analysis were conducted. Forty (78.4%) older patients with gastrointestinal cancer were considered frail. Flail group had a lower BMI (p < .001), thinner calf (p = .023), and lower quality of life (p = .04) compared to the non-frail group. Conclusion: This study showed the characteristics of frail patients with gastrointestinal cancer when changing anticancer drug regimen and the population that is vulnerable to falling into the frail cycle. The assessment of frailty in older cancer patients receiving anticancer drugs was an essential factor for QOL-conscious treatment decision. |
Practice | Nursing |
Keywords | Chemotherapy, Older cancer patient, Frailty, Quality of Life |
- 全文ダウンロード: 従量制、基本料金制の方共に770円(税込) です。
参考文献
- 浅海くるみ, 村上好恵(2017) : 外来化学療法を受ける転移・再発乳がん患者に生じる複数の症状の主観的体験と対処に関する質的研究, 日看科会誌, 37, 417-425.
- Aparicio, T., Jouve, J. L., Teillet, L., et al. (2013) : Geriatric factors predict chemotherapy feasibility : Ancillary results of FFCD 2001-02 phase III study in first-line chemotherapy for metastatic colorectal cancer in elderly patients, J. Clin. Oncol., 31(11), 1464-1470.
- Bellera, C. A., Rainfray, M., Mathoulin-Pelissier, S., et al. (2012) : Screening older cancer patients : First evaluation of the G-8 geriatric screening tool, Ann. Oncol., 23(8), 2166-2172.
- Budczies, J., von Winterfeld, M., Klauschen, F., et al. (2015) : The landscape of metastatic progression patterns across major human cancers, Oncotarget, 6(1), 570-583.
- Caillet, P., Liuu, E., Raynaud Simon, A., et al. (2017) : Association between cachexia, chemotherapy and outcomes in older cancer patients : A systematic review, Clin. Nutr., 36(6), 1473-1482.
残りの22件を表示する
- 大腸研究会(2019) : JSCCR Guidelines 2019 for the Treatment of Colorectal Cancer, Retrieved from : http://www.jsccr.jp/en/index.html
- Ethun, C. G., Bilen, M. A., Jani, A. B., et al. (2017) : Frailty and cancer : Implications for oncology surgery, medical oncology, and radiation oncology, CA Cancer J. Clin., 67(5), 362-377.
- Fried, L. P., Tangen, C. M., Walston, J., et al. (2001) : Frailty in older adults : Evidence for a phenotype, J. Gerontol. A Biol. Sci. Med., Sci, 56(3), 146-156.
- Handforth, C., Clegg, A., Young, C., et al. (2015) : The prevalence and outcomes of frailty in older cancer patients : A systematic review, Ann. Oncol., 26(6), 1091-1101.
- 本間照(1991) : Instrumental Activities of Daily Living(IADL), 本間照・大塚俊男編, 高齢者のための知的機能検査の手引き, 95-99, ワールドプランニング, 東京
- 石井亮, 小川武則, 高橋昌宏, 他(2018) : 頭頸部癌における高齢者機能評価スクリーニングツールの有用性, 頭頸部外科, 28(1), 55-61.
- Landi, F., Onder, G., Russo, A., et al. (2014) : Calf circumference, frailty and physical performance among older adults living in the community, Clin. Nutr., 33(3), 539-544.
- Lund, C. M., Vistisen, K. K., Olsen, A. P., et al. (2021) : The effect of geriatric intervention in frail older patients receiving chemotherapy for colorectal cancer : A randomised trial(GERICO), Br. J. Cancer, 124(12), 1949-1958.
- 亀山仁史, 島田能史, 八木亮磨, 他(2017) : EQ-5D-5Lスコアを用いた大腸癌術後患者Quality of Life評価, 癌と化学療法, 44(12), 1083-1085.
- 国立がん研究センターがん情報サービス : がんの統計'18, Retrieved from : https://ganjoho.jp/en/professional/statistics/brochure/2018_en.html
- Miyaji, T., Iioka, Y., Kuroda, Y., et al. (2017) : Japanese translation and linguistic validation of the US National Cancer Institute's Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events(PRO-CTCAE), J. Patient. Rep. Outcomes, 1, 8. doi : 10.1186/s41687-017-0012-7
- Mizutani, T., Nakamura, K., Fukuda, H., et al. (2019) : Geriatric research policy : Japan Clinical Oncology Group(JCOG)policy, Japanese Journal of Clinical Oncology, 49.10.1093/jjco/hyz093.
- Nakazawa, J., Kawahira, M., Kawahira, M., et al. (2021) : Analysis of factors affecting progression-free survival of first-line chemotherapy in older patients with advanced gastrointestinal cancer, Japanese Journal of Clinical Oncology, 12(8), 1200-1207.
- 日本胃癌学会(2018) : 胃癌治療ガイドライン 第5版 医師用, 25-31, 金原出版, 東京.
- 日本臨床腫瘍学会, 日本癌治療学会編集(2019) : 高齢者のがん薬物療法ガイドライン, 2-6, 南江堂, 東京.
- Quan, H., Li, B., Couris, C. M., et al. (2011) : Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries, Am. J. Epidemiol., 173(6), 676-682.
- Shiroiwa, T., Ikeda, S., Noto, S., et al. (2016) : Comparison of value set based on DCE and/or TTO data : Scoring for EQ-5D-5L health states in Japan, Value health, 19(5), 648-654.
- Sjoquist, K. M., Friedlander, M. L., O'Connell, R. L., et al. (2013) : Hope, quality of life, and benefit from treatment in women having chemotherapy for platinum-resistant /refractory recurrent ovarian cancer : The gynecologic cancer intergroup symptom benefit study, Oncologist, 18(11), 1221-1228.
- Townsley, C. A., Selby, R., Siu, L. L. (2005) : Systematic review of barriers to the recruitment of older patients with cancer onto clinical trials, J. Clin. Oncol., 23(13), 3112-3124.
- Wildiers, H., Heeren, P., Puts, M., et al. (2014) : International Society of Geriatric Oncology consensus on geriatric assessment in older patients with cancer, J. Clin. Oncol., 32(24), 2595-2603.
- Williams, G. R., Deal, A. M., Sanoff, H. K, et al. (2019) : Frailty and health-related quality of life in older women with breast cancer, Support. Care Cancer, 27(7), 2693-2698.
- World Health Organization(2001) : Men, ageing and health : a chieving health across the life span, Retrieved from : https://apps.who.int/iris/handle/10665/66941