アブストラクト
Japanese
| Title | 花粉-食物アレルギー症候群 (PFAS) における交差反応性の最新情報 |
|---|---|
| Subtitle | シンポジウム6 交差反応 成人食物アレルギーについて |
| Authors | 近藤康人 |
| Authors (kana) | |
| Organization | 藤田医科大学ばんたね病院小児科 |
| Journal | 日本小児アレルギー学会誌 |
| Volume | 37 |
| Number | 1 |
| Page | 54-59 |
| Year/Month | 2023 / |
| Article | 報告 |
| Publisher | 日本小児アレルギー学会 |
| Abstract | 「抄録:」花粉症患者が花粉アレルゲンと交差反応するタンパク質を含む植物性食物を摂取して即時型アレルギー症状を起こす病態を花粉-食物アレルギー症候群(PFAS:pollen-food allergy syndrome)と呼ぶ. 多くは花粉や果物に含まれるBet v 1ファミリーの交差抗原性によって引き起こされる. Bet v 1ファミリーのアレルゲンは加熱や胃酸でIgEエピトープが消失するため, 加工食品は食べられ, 症状は口腔内に限局するOral allergy syndrome(OAS)の臨床病型をしめす. 一方, ヒノキ科花粉症患者に果物によるOASが南欧で報告され, 原因としてGibberellin-regulated protein(GRP)の関与が報告された. 元来, 重篤な桃アレルギーの原因として報告されたGRPは低分子ながらS-S結合が6対あるため加熱や消化酵素に耐性を有し, 腸管で感作されると考えられている. しかし最近スギ花粉のアレルゲン(Cry j 7)としても報告されたことから, PFASへの関与について注目されている. |
| Practice | 臨床医学：内科系 |
| Keywords | 花粉-食物アレルギー症候群, 果物アレルギー, 口腔アレルギー症候群, 交差反応, ジベレリン制御タンパク質, cross reactivity, fruit allergy, GRP (Gibberellin-regulated protein), OAS (oral allergy syndrome), PFAS (pollen-food allergy syndrome) |
English
| Title | Pollen-food Allergy syndrome : Clinical features Up to date |
|---|---|
| Subtitle | |
| Authors | Yasuto Kondo |
| Authors (kana) | |
| Organization | Department of Pediatrics, Fujita Health University Bantane Hospital |
| Journal | The Japanese Journal of Pediatric Allergy and Clinical Immunology |
| Volume | 37 |
| Number | 1 |
| Page | 54-59 |
| Year/Month | 2023 / |
| Article | Report |
| Publisher | Japanese Society of Pediatric Allergy and Clinical Immunology |
| Abstract | [Summary:] People with pollen allergy may cause allergic reactions immediately following ingestion of certain uncooked plant foods containing cross-reacting proteins to pollen allergen, which pathology is called pollen-food allergic syndrome. It is caused by the cross-antigenicity of the protein family of Bet v 1 homologues found in pollen and fruits. Symptoms are less likely to occur if the product is heat-treated. This is due to the heat-labile and denaturable three-dimensional structure of this protein. On the other hand, people with cypress pollen allergy who experienced allergy to fruits, have been reported in southern France, and the involvement of allergen 'Gibberellin-regulated protein (GRP)' is a causative antigen in PFAS. GRP is a protein reported as the cause of severe peach allergies. Although it is a small molecule, it has 6 pairs of S-S bounds, it has a stable three-dimensional structure against heat, and has a strong resistance to digestive enzymes, so it can be sensitized to the intestinal tract. Therefore, the problem is that the allergic symptoms spread to the whole body and allergic symptoms become severe. Since it has also been reported in Japanese cedar pollen, GRP is expected to become an important issue in PFAS in Japan. |
| Practice | Clinical internal medicine |
| Keywords | cross reactivity, fruit allergy, GRP (Gibberellin-regulated protein), OAS (oral allergy syndrome), PFAS (pollen-food allergy syndrome) |
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
参考文献
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