アブストラクト
Japanese
| Title | 食物依存性運動誘発アナフィラキシーの病態 〜食物抗原の腸管吸収に影響する二次的因子〜 |
|---|---|
| Subtitle | 総説 |
| Authors | 横大路智治1), 松尾裕彰2) |
| Authors (kana) | |
| Organization | 1)広島大学大学院医系科学研究科薬物療法開発学研究室, 2)広島大学病院薬剤部 |
| Journal | 日本小児アレルギー学会誌 |
| Volume | 38 |
| Number | 5 |
| Page | 460-465 |
| Year/Month | 2024 / |
| Article | 報告 |
| Publisher | 日本小児アレルギー学会 |
| Abstract | 「抄録:」 食物依存性運動誘発性アナフィラキシー(FDEIA)は, 原因となる食物を摂取した後の運動負荷により蕁麻疹や呼吸困難などの症状を呈するimmunoglobulin E依存性の食物アレルギーである. 運動負荷以外にも, 非ステロイド性抗炎症薬の服用やアルコール摂取, 感染症, ストレスなどがFDEIA症状の誘発や増悪に関連する二次的因子として報告されている. 臨床研究や動物モデルを用いた解析により, 二次的因子は, 腸管上皮細胞間のタイトジャンクションを傷害して抗原の吸収を亢進させることやマスト細胞などの免疫細胞の活性化閾値を低下させることで, FDEIA症状の誘発や増悪に寄与することが明らかになってきた. 本総説では, 抗原の腸管吸収の亢進に着目して, 二次的因子によるFDEIA症状の誘発機序を概説する. 二次的因子の作用機序を解明することは, 新たな二次的因子を同定する手掛かりとなる. また, 作用機序を制御できる手法を探索すれば, 除去食療法に代わるFDEIAの新たな予防・治療法の開発につながる可能性がある. |
| Practice | 臨床医学：内科系 |
| Keywords | 吸収, 抗原, 二次的因子, 食物依存性運動誘発アナフィラキシー, absorption, allergen, cofactor, food-dependent exercise-induced anaphylaxis |
English
| Title | Pathogenesis of food-dependent exercise-induced anaphylaxis-cofactors enhancing intestinal absorption of food allergen |
|---|---|
| Subtitle | |
| Authors | Tomoharu Yokooji1), Hiroaki Matsuo2) |
| Authors (kana) | |
| Organization | 1)Department of Frontier Science for Pharmacotherapy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 2)Department of Pharmaceutical Services, Hiroshima University Hospital |
| Journal | The Japanese Journal of Pediatric Allergy and Clinical Immunology |
| Volume | 38 |
| Number | 5 |
| Page | 460-465 |
| Year/Month | 2024 / |
| Article | Report |
| Publisher | Japanese Society of Pediatric Allergy and Clinical Immunology |
| Abstract | [Summary:] Food-dependent exercise-induced anaphylaxis (FDEIA) is an immunoglobulin E (IgE)-mediated food allergy that is triggered by consuming the causative foods followed by physical exercise. Patients with FDEIA typically exhibit allergic symptoms such as generalized urticaria and dyspnea. In addition to physical exercise, several cofactors have been reported to induce or exacerbate FDEIA symptoms, including the use of non-steroidal anti-inflammatory drugs, alcohol consumption, infectious diseases, and acute stress. Clinical studies and animal experiments have shown that various cofactors might induce or exacerbate FDEIA symptoms by increasing the gastrointestinal permeability of ingested allergens through impaired tight junctions between intestinal epithelial cells and by lowering the threshold for IgE-mediated mast cell degranulation. In this review, we summarized the mechanisms by which cofactors induce FDEIA symptoms, focusing on the increased intestinal permeability of food allergens. Elucidating the mechanisms of cofactors may help identify new cofactors and lead to novel prophylactic and therapeutic strategies for patients with FDEIA, offering alternatives to elimination diets. |
| Practice | Clinical internal medicine |
| Keywords | absorption, allergen, cofactor, food-dependent exercise-induced anaphylaxis |
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
