アブストラクト
| Title | 経鼻弱毒生ワクチン (LAIV) と不活化インフルエンザワクチン (IIV) |
|---|---|
| Subtitle | 特集 予防接種の話題と課題 |
| Authors | 菅谷憲夫 |
| Authors (kana) | |
| Organization | 慶應義塾大学医学部 客員教授, 前 神奈川県警友会けいゆう病院 感染制御センター長 |
| Journal | 東京小児科医会報 |
| Volume | 42 |
| Number | 2 |
| Page | 27-33 |
| Year/Month | 2024 / 3 |
| Article | 報告 |
| Publisher | 東京小児科医会 |
| Abstract | 「要旨」 経鼻弱毒生インフルエンザワクチン(LAIV)は2023年3月, 2歳以上19歳未満を対象に日本でも認可され, 2024年秋から本格的に導入されることになった. 2016-17年に国内第3相試験が実施され, 全インフルエンザに対する発病防止効果は28.8% (95%CI: 12.5-42.0)で, A(H3N2)に対する効果は28.8% (CI: 9.0-43.1)であった. またB型に対する効果は, 28.8% (CI: -42.2-64.3)で統計的に有意ではなかった. 年齢群別では, LAIVの主要な接種対象となる2-6歳群で有効ではなかった. LAIV接種に関連した重篤な有害事象は認められなかった. 米国ではLAIVがA (H1N1) pdm09に対して無効なことが報告され, 一時, 接種は中止されたことがある. 日本でも効果の検証が必須である. なお米国では, LAIVは自己投与または介護者による投与の申請中である. |
| Practice | 臨床医学：内科系 |
| Keywords |
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
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残りの11件を表示する
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