Articles of Alternatives to Animal Testing and Experimentation | Volume 11, Issue suppl / 2006

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Alternatives to Animal Testing and Experimentation

Volume 11, Issue suppl / 2006

English Article

Japanese Article

Please note that metadata of J-type articlesare generated by machine-translation and the original texts are written in Japanese.

	S1-1 Gene Expression Changes in vivo/in vitro Induced by Mutagens Takayoshi Suzuki Alternatives to Animal Testing and Experimentation 11(suppl): 212-212, 2006.

	S1-2 Evaluation of carcinogenicity on chemicals using transgenic mice Kunitoshi Mitsumori1), Miwa Okamura1), Meilan Jin1) Alternatives to Animal Testing and Experimentation 11(suppl): 213-213, 2006.

	S1-3 Establishment of humanized genotoxicity test system and its application to genotoxic and carcinogenic risk assessment Masamitsu Honma Alternatives to Animal Testing and Experimentation 11(suppl): 214-214, 2006.

	S1-4 Chemical compound profiling based on proteomics technology H Yamanaka1), Y Sudo1), Y Yakabe1), K Saito2), K Sumida2), M Sekijima3), K Nakayama3), T Shirai4) Alternatives to Animal Testing and Experimentation 11(suppl): 215-215, 2006.

	S1-5 Detection of tumor initiators and promoters using Bhas 42 cells Shin Asada, Kiyoshi Sasaki, Noriho Tanaka, Makoto Umeda Alternatives to Animal Testing and Experimentation 11(suppl): 216-216, 2006.

	S1-6 The present status of prevalidation study in ECVAM on alternative methods for screening carcinogenic chemicals Makoto Umeda, Kiyoshi Sasaki, Noriho Tanaka Alternatives to Animal Testing and Experimentation 11(suppl): 217-217, 2006.

	S2-1 The Forefront of Alternatives to Animal Testing:the Search for a Breakthrough in In Vitro Toxicology Atsushige Sato1), Hiroshi Itagaki2) Alternatives to Animal Testing and Experimentation 11(suppl): 218-218, 2006.

	S2-2 Development of in vitro alternative assays for acute systemic toxicity, and skin genotoxicity test in vivo Noriho Tanaka1), Hiroshi Itagaki2), Shinobu Wakuri1), Masato Kitagaki2), Yuzuki Nakagawa1) Alternatives to Animal Testing and Experimentation 11(suppl): 219-219, 2006.

	S2-3 Prediction of skin permeability of compounds from their molecular structure Fumiyoshi Yamashita1), Hirokazu Kouzuki2), Hiroshi Itagaki2), Mitsuru Hashida1) Alternatives to Animal Testing and Experimentation 11(suppl): 220-220, 2006.

	S2-4 Evaluation of Drug-metabolizing Capacities of Cell Lines Using for Alternative Sensitization Tests Takemi Yoshida, Takashi Ashino, Makie Ishikawa, Satoshi Numazawa Alternatives to Animal Testing and Experimentation 11(suppl): 221-221, 2006.

	S2-5 Unresolved questions regarding sensitization by haptens Setsuya Aiba, Satoshi Nakagawa, Masato Mizuashi, Tomohiro Ohtani, Ikuko Numata Alternatives to Animal Testing and Experimentation 11(suppl): 222-222, 2006.

	S2-6 Development of an in vitro skin sensitization test (human Cell Line Activation Test; h-CLAT) using THP-1 cell (human monocytic leukemia cell line) Takao Ashikaga Alternatives to Animal Testing and Experimentation 11(suppl): 223-223, 2006.

	F-1 The situation of introduction of alternatives in the world Eriko Gotoh Alternatives to Animal Testing and Experimentation 11(suppl): 224-224, 2006.

	F-2 Proposal for Animal Body Donation Program in higher education in Japan Lee, Kenichi1), 2) Alternatives to Animal Testing and Experimentation 11(suppl): 225-225, 2006.

	F-3 Considering About An Anatomy Practice in The Academic Education (in Mainly Veterinary Section) 〜Aiming at the fulfillment of animal donation system 〜 Daisuke Nagaosa Alternatives to Animal Testing and Experimentation 11(suppl): 226-226, 2006.

	F-4 THE VETERINARY SURGERY TRAINING 〜The present state and problem〜 Kaisaku OTA1), 2) Alternatives to Animal Testing and Experimentation 11(suppl): 227-227, 2006.

	S3-1 Cutaneous allergy Setsuya Aiba Alternatives to Animal Testing and Experimentation 11(suppl): 228-228, 2006.

	S3-2 Integrating in vitro data into skin sensitization risk assessments David Basketter Alternatives to Animal Testing and Experimentation 11(suppl): 228-228, 2006.

	S3-3 LLNA-DA and LLNA-BrdU Yukiko Kanazawa Alternatives to Animal Testing and Experimentation 11(suppl): 229-229, 2006.

	S3-4 Cell-based in vitro skin sensitization methods Hitoshi Sakaguchi Alternatives to Animal Testing and Experimentation 11(suppl): 230-230, 2006.

	S3-5 Hapten-protein/peptide binding assay as a screening method for skin sensitiztaion Yosuke Nakamura Alternatives to Animal Testing and Experimentation 11(suppl): 231-231, 2006.

	S3-6 Convenient in-silico Toxicity assessment via TOPKAT Takeshi Saito Alternatives to Animal Testing and Experimentation 11(suppl): 231-231, 2006.

	S3-7 Prediction for skin sensitization using Derek for Windows Hiroko Akiyama Alternatives to Animal Testing and Experimentation 11(suppl): 232-232, 2006.

	P-01 Studies on the prediction of photochemical carcinogenesis induced by quinolone antimicrobial agents Kenji Inoue, Riichirou Yonezawa, Katsuaki Kubota Alternatives to Animal Testing and Experimentation 11(suppl): 233-233, 2006.

	P-02 Inter-laboratory Collaborative Study of Cell Transformation Assay for Tumor Promoters Using Bhas 42 cells by Non-genotoxic Carcinogen Study Group in Japan Kiyomi Ohmori 1), Makoto Umeda 2), Noriho Tanaka 2), Hiroki Takagi 3), Isao Yoshimura 4), Kiyoshi Sasaki 2), Shin Asada 2), Ayako Sakai 5), Masumi Asakura 7), Hiroshi Baba 8), Yuichi Fushiwaki 1), Shuichi Hamada 9), Nobuko Kitou 6), Tetsu Nakamura 10), Yoshiyuki Nakamura 11), Hidetoshi Oishi 12), Satoshi Sasaki 13), Sawako Shimada 14), Toshiyuki Tsuchiya 15), Yoshifumi Uno 8), Masataka Washizuka 16), Satoshi Yajima 13), Yasuhito Yamamoto 17), Eiji Yamamura 8), Tomoko Yatsushiro 10) Alternatives to Animal Testing and Experimentation 11(suppl): 234-234, 2006.

P-02 Inter-laboratory Collaborative Study of Cell Transformation Assay for Tumor Promoters Using Bhas 42 cells by Non-genotoxic Carcinogen Study Group in Japan
Kiyomi Ohmori 1), Makoto Umeda 2), Noriho Tanaka 2), Hiroki Takagi 3), Isao Yoshimura 4), Kiyoshi Sasaki 2), Shin Asada 2), Ayako Sakai 5), Masumi Asakura 7), Hiroshi Baba 8), Yuichi Fushiwaki 1), Shuichi Hamada 9), Nobuko Kitou 6), Tetsu Nakamura 10), Yoshiyuki Nakamura 11), Hidetoshi Oishi 12), Satoshi Sasaki 13), Sawako Shimada 14), Toshiyuki Tsuchiya 15), Yoshifumi Uno 8), Masataka Washizuka 16), Satoshi Yajima 13), Yasuhito Yamamoto 17), Eiji Yamamura 8), Tomoko Yatsushiro 10)
Alternatives to Animal Testing and Experimentation 11(suppl): 234-234, 2006.

	P-03 Effects of polychlorinated biphenyls on cultured rat embryos Masaharu Akita1), Mari Kato1), Atsushi Yokoyama2), Koichi Haraguchi3), Nobuyuki Koga4), Yukiaki Kuroda5) Alternatives to Animal Testing and Experimentation 11(suppl): 235-235, 2006.

	P-04 Effects of Kalesite (KS) used as a conjugated drug with environmental chemical on cultured rat embryos A. Yokoyama1), H. Yokoyama2), E. A. Johnston2), M. Akita3), Yukiaki Kuroda4) Alternatives to Animal Testing and Experimentation 11(suppl): 235-235, 2006.

	P-05 Novel protocol for evaluation of respiratory sensitizers: -Availability for chemical materials- Yamagishi Gaku1), Aoyama Kohji2), Idehara Kenji1), Uemori Takeshi1), Takeuchi Toru2), Yamashita Kunihiko1) Alternatives to Animal Testing and Experimentation 11(suppl): 236-236, 2006.

	P-06 Novel protocol for evaluation of respiratory sensitizers: Quantitative evaluation Kohji Aoyama1), Gaku Yamagishi2), Kenji Idehara2), Takeshi Uemori2), Baohui Xu3), Toru Takeuchi1), Kunihiko Yamashita2) Alternatives to Animal Testing and Experimentation 11(suppl): 237-237, 2006.

	P-07 Results of a Japanese ring study of a Human Cell Line Activation Test (h-CLAT) for predicting skin sensitization potential (1st report) Ashikaga Takao1), Sakaguchi Hitoshi2), Okamoto Kenji3), Mizuno Makoto4), Yamada Takaaki5), Yoshida Mayumi6), Sato Jun7), Kodama Tatsuji7), Ohta Naoko6), Hasegawa Seiji5), Okamoto Yuko4), Kuwahara Hirofumi3), Kosaka Nanae2), Sono Sakiko1), Ohno Yasuo8) Alternatives to Animal Testing and Experimentation 11(suppl): 238-238, 2006.

P-07 Results of a Japanese ring study of a Human Cell Line Activation Test (h-CLAT) for predicting skin sensitization potential (1st report)
Ashikaga Takao1), Sakaguchi Hitoshi2), Okamoto Kenji3), Mizuno Makoto4), Yamada Takaaki5), Yoshida Mayumi6), Sato Jun7), Kodama Tatsuji7), Ohta Naoko6), Hasegawa Seiji5), Okamoto Yuko4), Kuwahara Hirofumi3), Kosaka Nanae2), Sono Sakiko1), Ohno Yasuo8)
Alternatives to Animal Testing and Experimentation 11(suppl): 238-238, 2006.

	P-08 Study on optimization of in vitro sensitization assay using THP-1cells Sakiko Sono, Kasturako Yoneyama, Takao Ashikaga, Hiroshi Itagaki Alternatives to Animal Testing and Experimentation 11(suppl): 239-239, 2006.

	P-09 Evaluation of changes of cell surface thiols as a new biomarker for in vitro sensitization (I): The accuracy of in vitro assay vs. in vivo assay Mie Suzuki1), Morihiko Hirota1), Shigenobu Hagino1), Hiroshi Itagaki1), Setsuya Aiba2) Alternatives to Animal Testing and Experimentation 11(suppl): 240-240, 2006.

	P-10 Evaluation of changes of cell surface thiols as a new biomarker for in vitro sensitization assay (II): the comparison between cell lines. Morihiko Hirota1), Mie Suzuki1), Shigenobu Hagino1), Hiroshi Itagaki1), Setsuya Aiba2) Alternatives to Animal Testing and Experimentation 11(suppl): 241-241, 2006.

	P-11 The cross-link between the reduced cell surface thiols and the oxidized GSH/GSSG ratio in monocyte-derived dendritic cells treated with haptens Yosinori Sasaki1), Masato Mizuashi1), Morihiko Hirota2), Mie Suzuki2), Hiroshi Itagaki2), Setsuya Aiba1) Alternatives to Animal Testing and Experimentation 11(suppl): 242-242, 2006.

	P-12 Development of a peptide binding assay for predicting contact dermatitis. Hoya M., Kanda K., Kouzuki H., Hagino S., Itagaki H. Alternatives to Animal Testing and Experimentation 11(suppl): 243-243, 2006.

	P-13 Skin sensitization test with human monocytic leukemia cell line in fragrances Yoshikazu Naoe, Makoto Mizuno, Noriyasu Imai, Miki Nakanishi, Kei Kusai, Yuko Okamoto Alternatives to Animal Testing and Experimentation 11(suppl): 244-244, 2006.

	P-14 The response pattern of THP-1 cells to allergens and mechanisms of allergen-induced THP-1 cell activation Masaaki Miyazawa, Yuichi Ito, Nanae Kosaka, Hitoshi Sakaguchi, Hiroyuki Suzuki Alternatives to Animal Testing and Experimentation 11(suppl): 245-245, 2006.

	P-15 Role of mitogen-activated protein kinase in CD86/CD54 expression induced by contact sensitizers on THP-1 cells Yuichi Ito, Masaaki Miyazawa, Yukiko Yoshida, Nanae Kosaka, Hitoshi Sakaguchi, Hiroyuki Suzuki Alternatives to Animal Testing and Experimentation 11(suppl): 246-246, 2006.

	P-16 Investigation of co-stimulatory molecules expression and cytokines production in THP-1 human monocyte cell line treated with skin sensitizers Makoto Mizuno, Noriyasu Imai, Miki Nakanishi, Yoshikazu Naoe, Kei Kusai, Yuko Okamoto Alternatives to Animal Testing and Experimentation 11(suppl): 247-247, 2006.

	P-17 Evaluation of Drug-metabolizing Capacities of Cell Lines Using for Alternative Tests - with Special Reference to Alterenative Sensitization Test Takemi Yoshida1), Takashi Ashino1), Makie Ishikawa1), Masaaki Mori2), Shigenobu Hagino2), Hiroshi Itagaki2), Satoshi Numazawa1) Alternatives to Animal Testing and Experimentation 11(suppl): 248-248, 2006.

	P-18 Construction of three-dimensional human skin model consisting of dendritic cells, keratinocytes and fibroblasts Tadashi Uchino, Hiroshi Tokunaga Alternatives to Animal Testing and Experimentation 11(suppl): 249-249, 2006.

	P-19 Reproducibility of human 3-dimensional cultured epidermal model (LabCyte EPI-MODEL) for an alternative to animal testing Kubo Kentaro, Kuchiike Daisuke, Shigeta Tomomi, Hamajima Fumiyasu, Katoh Masakazu Alternatives to Animal Testing and Experimentation 11(suppl): 250-250, 2006.

	P-20 The morphological and functional study of human 3-dimensional cultured epidermal model (LabCyte EPI-MODEL) -Evaluation of proliferation, differentiation and secreted cytokines- Hamajima Fumiyasu, Kubo Kentaro, Katoh Masakazu, Hata Ken-ichiro Alternatives to Animal Testing and Experimentation 11(suppl): 251-251, 2006.

	P-21 Skin irritant tests using human 3-dimensional cultured epidermal model (LabCyte EPI-MODEL) -Analysis by inflammatory cytokines- Hamajima Fumiyasu, Kubo Kentaro, Katoh Masakazu, Hata Ken-ichiro Alternatives to Animal Testing and Experimentation 11(suppl): 252-252, 2006.

	P-22 Evaluation of skin irritation using cultured cells -Effect of skin concentration and applied period on the skin irritation- Yoshifumi Takinoue1), Hiroshi Ishii1), Satoshi Kano2), Hiroaki Todo1), Kenji Sugibayashi1) Alternatives to Animal Testing and Experimentation 11(suppl): 253-253, 2006.

	P-23 In vitro micronucleus test using rat FRSK cells. Yuzuki Nakagawa, Noriho Tanaka Alternatives to Animal Testing and Experimentation 11(suppl): 254-254, 2006.

	P-24 Vitrigel-sandwich culture system useful for maintaining the functions of rat primary hepatocytes Yukiko NAKAZAWA1, 2, Koichi UENO2, Toshiaki TAKEZAWA1 Alternatives to Animal Testing and Experimentation 11(suppl): 255-255, 2006.

	P-25 Development of a new three-dimensional culture of human hepatocytes Tatsuya Yamaguchi1, Takuya Ishibashi1, Kouji Nakazawa2, Hiroshi Mizumoto3, Kazumori Funatsu4 Alternatives to Animal Testing and Experimentation 11(suppl): 256-256, 2006.

	P-26 Gene Expression Analysis of Liver Cells in Double-layered Coculture Systems with Small Intestinal Cells in the Presence of Xenobiotics Masaki Nishikawa1), Nobuhiko Kojima1), Emiko Kitagawa2), Hitoshi Iwahashi2), Takatoki Yamamoto1), Teruo Fujii1), Yasuyuki Sakai1), 3) Alternatives to Animal Testing and Experimentation 11(suppl): 257-257, 2006.

	P-27 Construction of the in vitro transporter experimental systems for prediction of the dexification of drugs in human liver: Utilization of human cryopreserved hepatocytes and double transfectants Kazuya Maeda, Masaru Hirano, Naoki Ishiguro, Satoshi Kitamura, Wakaba Yamashiro, Soichiro Matsushima, Yuichi Sugiyama Alternatives to Animal Testing and Experimentation 11(suppl): 258-258, 2006.

	P-28 An evaluation for cytotoxicity and cell transformation by the measurement of glucose consumption in media Masanori Wada1), Tomokatsu Hongo1), Shinobu Wakuri2), Yoichi Ishikawa1), Makoto Umeda2), Noriho Tanaka2) Alternatives to Animal Testing and Experimentation 11(suppl): 259-259, 2006.

	P-29 Correlation of the results between Peptide-Binding Assay using LC-mass spectrometry and LLNA Takashi Morimoto, Yosuke Nakamura, Tamaki Higaki, Kazuko Yamashita, Masahiko Okamoto, Mika Ota, Kazuhiko Nishioka Alternatives to Animal Testing and Experimentation 11(suppl): 260-260, 2006.

	P-30 The influence of light source and cell line on in vitro phototoxicity tests Noriyasu Imai1), Shinobu Otani2), Makoto Mizuno1), Yoshikazu Naoe1), Miki Nakanishi1), Yuko Okamoto1) Alternatives to Animal Testing and Experimentation 11(suppl): 261-261, 2006.

	P-31 Irradiation conditions and its effects in photoclastogenicity test in vitro Kohji YAMAKAGE, Toshitaka TAKAHASHI, Shin ASADA, Noriho TANAKA Alternatives to Animal Testing and Experimentation 11(suppl): 262-262, 2006.

	P-32 Alternative test for in vivo acute systemic toxicity (3): Comparative evaluation of Collagen gel assay in two laboratories for predicting in vivo acute systemic toxicity M. Kitagaki 1), S. Wakuri 2), N. Tanaka 2), H. Itagaki 1) Alternatives to Animal Testing and Experimentation 11(suppl): 263-263, 2006.

	P-33 Application of in vitro cytotoxicity test for alternative method to systemic toxicity in vivo - metabolic activation system and treatment period - Shinobu Wakuri1), Yasuo Ohno2), Noriho Tanaka1) Alternatives to Animal Testing and Experimentation 11(suppl): 264-264, 2006.

	P-34 Educational Issue of 3Rs in Japan Yukihisa Matsuda1), Tsutomu Miki Kurosawa2) Alternatives to Animal Testing and Experimentation 11(suppl): 265-265, 2006.

	P-35 The current Japanese students' activities for alternatives in veterinary education Eriko Gotoh Alternatives to Animal Testing and Experimentation 11(suppl): 266-266, 2006.

	P-36 The Depth of Ketamine Based Anesthesia Evaluated by Visual Evoked Potentials in Mice Shoko Obora1), Masaru Tajima1), Tomomitsu Miyoshi2), Hajime Sawai2), Tsutomu Kurosawa1) Alternatives to Animal Testing and Experimentation 11(suppl): 267-267, 2006.

	P-37 Statistical Considerations for Allocation and the Number of Time Points in a ET50 Estimation Using Three Dimensional Human Skin Model Takashi Sozu1), Masayuki Takanuma2), Ayako Shiraishi2), Chikuma Hamada1), Isao Yoshimura1) Alternatives to Animal Testing and Experimentation 11(suppl): 268-268, 2006.

	P-38 A Statistical Method for Estimating ET50 Using Small Size Data Ayako Shiraishi1), Yohei Hyodo1), Takashi Sozu2), Chikuma Hamada2), Isao Yoshimura2) Alternatives to Animal Testing and Experimentation 11(suppl): 269-269, 2006.

	P-39 Consideration on the statistical analysis for agar method in the mouse lymphoma assay Isao Yoshimura Alternatives to Animal Testing and Experimentation 11(suppl): 270-270, 2006.

	P-40 Development of the inclusive evaluation method for the percutaneous absorption III: Prediction of human dermal concentration of chemicals in various vehicles Hirokazu Kouzuki1), Fumiyoshi Yamashita2), Hiroshi Itagaki1), Mitsuru Hashida2) Alternatives to Animal Testing and Experimentation 11(suppl): 271-271, 2006.

	P-41 Strategy for (Q)SAR evaluation of chemical genotoxicity M. Hayashi1), E. Kamata2), A. Hirose2), M. Takahashi2), T. Morita3), M. Ema2) Alternatives to Animal Testing and Experimentation 11(suppl): 272-272, 2006.

	P-42 Establishment of in silico systems to predict the effects of genetic polymorphism on the enzymatic activity of cytochrome P450 Ayako Tokumitsu1), Kazuma Kiyotani2), Shunsuke Iwano2), Hiroshi Yamazaki2), Tetsuya Kamataki2), Yoshinori Mitamura1) Alternatives to Animal Testing and Experimentation 11(suppl): 273-273, 2006.

	P-43 Influence of hypothyrodism induced by thiamazole on the drug interaction in chick embryos Yuji Yoshiyama, Michiko Shioiri, Tomomi Ikeda, Ayumi Sato, Kazumi Kanai, Motoko Kanke Alternatives to Animal Testing and Experimentation 11(suppl): 274-274, 2006.

	P-44 Search for anti-aging effects of herbs and kampo using lifespan analyses of the nematode C. elegans as a marker. Takurou Yamaguchi1), 2), Michio Tsuda1), Makoto Arai3), Yasunori Nishio2), Naoak Ishii1), 2) Alternatives to Animal Testing and Experimentation 11(suppl): 275-275, 2006.