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Alternatives to Animal Testing and Experimentation

Volume 27, Issue suppl / 2022
English Article   Japanese Article
  • Please note that metadata of J-type articlesare generated by machine-translation and the original texts are written in Japanese.
English Article SL-1. Utilization of biomarkers for detection and prediction of transporter-mediated drug interaction risk
Hiroyuki Kusuhara
Alternatives to Animal Testing and Experimentation 27(suppl): 84-84, 2022.
English Article SL-2. Promotion of proper conduct of animal experiments
Ichiro Miyoshi
Alternatives to Animal Testing and Experimentation 27(suppl): 84-84, 2022.
English Article SL-3. Data-driven drug discovery and healthcare by AI
Yoshihiro Yamanishi
Alternatives to Animal Testing and Experimentation 27(suppl): 85-85, 2022.
English Article EL. Past and future of research on alternative methods for animal experiments in Japan : Wen old wisdom new about 35 years of research on alternative methods
Hiroshi Itagaki
Alternatives to Animal Testing and Experimentation 27(suppl): 85-85, 2022.
English Article S1-1. Update on skin sensitisation and safety evaluation
David Basketter
Alternatives to Animal Testing and Experimentation 27(suppl): 86-86, 2022.
English Article S1-2. Introduction of validation study for new in chemico spectro-DPRA developed in Korea
Bae-Hwan Kim
Alternatives to Animal Testing and Experimentation 27(suppl): 86-86, 2022.
English Article S1-3. Experimentally validated in-silico approach to predict the skin sensitization potential of phytochemicals
Rahul Date, Bharath Rudresh, Priyanka Mishra, Nitin Patel, Vaibhav Barot, Kirti Shitiz, Fatima Khan, Ashita Desai, Abhishek Tater, Abhay Deshpande
Alternatives to Animal Testing and Experimentation 27(suppl): 87-87, 2022.
English Article S1-4. Establishment and international harmonization of photosafety testing strategy
Satomi Onoue
Alternatives to Animal Testing and Experimentation 27(suppl): 87-87, 2022.
English Article S1-5. JSAAE strategy for international cooperation
Hajime Kojima
Alternatives to Animal Testing and Experimentation 27(suppl): 88-88, 2022.
English Article S2-1. In silico modeling & simulation for efficient inhalation toxicity testing on chemicals
Kohei Yamada1), Atsushi Kambayashi1,2), Hideyuki Sato1), Satomi Onoue1)
Alternatives to Animal Testing and Experimentation 27(suppl): 88-88, 2022.
English Article S2-2. Prediction of internal concentrations of chemicals using data-driven pharmacokinetic modeling
Hiroshi Yamazaki
Alternatives to Animal Testing and Experimentation 27(suppl): 89-89, 2022.
English Article S2-3. Modeling & simulation approach for prediction of pharmacokinetics of antibody drugs
Kazuhisa Ozeki
Alternatives to Animal Testing and Experimentation 27(suppl): 89-89, 2022.
English Article S2-4. Predicting the in vivo performance of oral dosage forms using a modeling and simulation approach
Atsushi Kambayashi
Alternatives to Animal Testing and Experimentation 27(suppl): 90-90, 2022.
English Article S3-1. Neurotoxicity assessment of compounds based on in vitro neural activity
Ikuro Suzuki
Alternatives to Animal Testing and Experimentation 27(suppl): 90-90, 2022.
English Article S3-2. Evaluation of developmental neurotoxicity of chemical substances by a read-across method using chemical structure information
Kouichi Yoshinari
Alternatives to Animal Testing and Experimentation 27(suppl): 91-91, 2022.
English Article S3-3. Current status and challenges of developmental neurotoxicity testing using zebrafish
Yuhei Nishimura
Alternatives to Animal Testing and Experimentation 27(suppl): 91-91, 2022.
English Article S3-4. Current status and future perspectives in in vitro neurotoxicity
Yasunari Kanda, Yukuto Yasuhiko
Alternatives to Animal Testing and Experimentation 27(suppl): 91-91, 2022.
English Article S4-1. Update of immunotoxicology : new approach methodologies with a focus on immunosuppression
Emanuela Corsini
Alternatives to Animal Testing and Experimentation 27(suppl): 92-92, 2022.
English Article S4-2. AOP development of immunotoxicity in OECD AOP programme
Kiyoshi Kushima
Alternatives to Animal Testing and Experimentation 27(suppl): 92-92, 2022.
English Article S4-3. Development of a Detailed Review Paper (DRP) on non-animal approaches for immunosuppression
Barbara Kaplan
Alternatives to Animal Testing and Experimentation 27(suppl): 93-93, 2022.
English Article S4-4. Expanding possibilities for Multi-Immuno Tox assay
Setsuya Aiba
Alternatives to Animal Testing and Experimentation 27(suppl): 93-93, 2022.
English Article S6-1. Practical use of alternative methods to animal testing in drug development - Mainly for drug candidate compound selection -
Kazunori Fujimoto
Alternatives to Animal Testing and Experimentation 27(suppl): 94-94, 2022.
English Article S6-2. Current status and issues for the use of alternative methods in the field of food
Yuichi Ito
Alternatives to Animal Testing and Experimentation 27(suppl): 95-95, 2022.
English Article S6-3. Conducting alternative testing method for the Pesticide Control Act
Tadashi Kosaka
Alternatives to Animal Testing and Experimentation 27(suppl): 95-95, 2022.
English Article S6-4. Current status and issues of alternative method utilization in cosmetics OEM / ODM
Nishiura Hideki
Alternatives to Animal Testing and Experimentation 27(suppl): 95-95, 2022.
English Article S6-5. Current status and issues of alternative method utilization in the CRO industry
Takayuki Fukuda
Alternatives to Animal Testing and Experimentation 27(suppl): 96-96, 2022.
English Article S7-1. Contribution to the 3Rs through the use of e-learning in the education of laboratory animal technicians
Mariko Amano, Hironari Koyama
Alternatives to Animal Testing and Experimentation 27(suppl): 96-96, 2022.
English Article S7-2. "Contents for Ethics Training on Animal Experiments" funded by the JH Research Promotion Fund
Noboru Ogiso
Alternatives to Animal Testing and Experimentation 27(suppl): 97-97, 2022.
English Article S7-3. Development and consideration of educational contents related to animal experiments
Ryuichi Miura
Alternatives to Animal Testing and Experimentation 27(suppl): 97-97, 2022.
English Article S8-1. Expectations and challenges for New Generation Risk Assessment (NGRA)
Morihiko Hirota
Alternatives to Animal Testing and Experimentation 27(suppl): 98-98, 2022.
English Article S8-2. Prediction of skin permeation of chemicals based on exposure scenario
Hiroaki Todo
Alternatives to Animal Testing and Experimentation 27(suppl): 98-98, 2022.
English Article S8-3. Consideration for safety assessment methods by NAM based on experience with in vivo toxicity studies
Yuhji Taquahashi
Alternatives to Animal Testing and Experimentation 27(suppl): 99-99, 2022.
English Article S8-4. Development of Next-Generation Risk Assessment (NGRA) case study and considerations for regulatory acceptance
Takashi Yamada
Alternatives to Animal Testing and Experimentation 27(suppl): 99-99, 2022.
English Article S9-1. Importance of image-based status monitoring for enabling iPS cell culture under QbD
Ryuji Kato
Alternatives to Animal Testing and Experimentation 27(suppl): 100-100, 2022.
English Article S9-2. Risk assessment of drug-induced arrhythmia using human iPS cell-derived cardiomyocytes
Junko Kurokawa
Alternatives to Animal Testing and Experimentation 27(suppl): 100-100, 2022.
English Article S9-3. Development of human iPS cell derived-brain microvascular endothelial cells in the BBB model for application in drug development
Tadahiro Hashita
Alternatives to Animal Testing and Experimentation 27(suppl): 101-101, 2022.
English Article S9-4. Toward in vitro reconstitution of brain function using organoids derived from monkey and human pluripotent stem cells
Fumitaka Osakada
Alternatives to Animal Testing and Experimentation 27(suppl): 101-101, 2022.
English Article A-1. Development of LLNA : DA
Kunihiko Yamashita
Alternatives to Animal Testing and Experimentation 27(suppl): 102-102, 2022.
English Article A-2. Construction of 3D-Living Tissues for Alternatives to Animals Experiments using Layer-by-Layer Methods on Affinity Interactions between ECM Proteins
Mitsuru Akashi
Alternatives to Animal Testing and Experimentation 27(suppl): 102-102, 2022.
English Article M-0. Mandom International Research Grants on Alternative to Animal Experiments
Hidefumi Ikeda
Alternatives to Animal Testing and Experimentation 27(suppl): 103-103, 2022.
English Article M-1. Development of an alternative evaluation system for the potential of mitochondrial permeability transition using human-isolated platelets
Akinori Takemura
Alternatives to Animal Testing and Experimentation 27(suppl): 103-103, 2022.
English Article M-2. Vascular endothelial spheroid as an evaluation tool for inflammatory response
Sanshiro Hanada
Alternatives to Animal Testing and Experimentation 27(suppl): 104-104, 2022.
English Article M-3. Development of alternatives to animal testing for predicting the health effects of chemicals on the human fetus
Takeshi Hori
Alternatives to Animal Testing and Experimentation 27(suppl): 104-104, 2022.
English Article P-01. False negative chemicals in ESR based photosafety test (ESR-PT) and their significances on photosafety evaluations
Masumi Hinoshita1), Takayuki Abe2), Yosuke Maeda3), Masahiro Takeyoshi3)
Alternatives to Animal Testing and Experimentation 27(suppl): 106-106, 2022.
English Article P-02. Micellar Reactive Oxygen species (ROS) assay using Acetonitrile for poorly water-soluble chemicals
Toshiyuki Ohtake
Alternatives to Animal Testing and Experimentation 27(suppl): 106-106, 2022.
English Article P-03. Read-across based on chemical structure information and non-animal test methods for skin sensitization potency prediction
Kanako Nakayama, Taisuke Kawamoto, Masaaki Miyazawa
Alternatives to Animal Testing and Experimentation 27(suppl): 107-107, 2022.
English Article P-04. Development of a method for evaluating inhalation toxicity potential of nanomaterials in a co-culture system of human bronchial epithelial cells and THP-1 cells
Asuka Nishida1), Takao Ashikaga2), Akiko Ohno2), Kazutoshi Iijima3)
Alternatives to Animal Testing and Experimentation 27(suppl): 107-107, 2022.
English Article P-05. Improvement and performance of highly accurate and simple KE-2 test method α-Sens(R)
Yosuke Maeda, Masahiro Takeyoshi
Alternatives to Animal Testing and Experimentation 27(suppl): 108-108, 2022.
English Article P-06. Search for novel inhibitors of atopic dermatitis using human keratinocyte cell lines as a model of atopic dermatitis
Ayano Satoh1), Kosuke Kato1), Yoshio Tsujino2)
Alternatives to Animal Testing and Experimentation 27(suppl): 108-108, 2022.
English Article P-07. Evaluation of predictive performance of the combination approaches for Skin Sensitization using a new KE-2 test method α-Sens(R)
Masaru Suzuki1), Mayuko tomisawa1), Saori Fujishima1), Yosuke Maeda2), Masahiro Takeyoshi2)
Alternatives to Animal Testing and Experimentation 27(suppl): 109-109, 2022.
English Article P-08. Improvement of the chromophore solid phase peptide reaction assay (C-SPRA) for rapid safety assessment as alternatives to animal testing
Kenji Usui1), Masae Fukuda1), Aki Nishimura1), Fumihiro Kayamori1), Yoshio Hamada1), Hideto Ariumi2)
Alternatives to Animal Testing and Experimentation 27(suppl): 109-109, 2022.
English Article P-09. Development of high-sensitivity detection reagents for trace skin sensitizers to improve the accuracy of skin sensitization test methods and identify positive causes
Masataka Kitadani1), Yohei Shimizu1), Hideyuki Mizumachi2), Taku Nishijo2), Takuo Yuki2), Akihiro Moriuchi1), Ryo Koike1)
Alternatives to Animal Testing and Experimentation 27(suppl): 110-110, 2022.
English Article P-10. Development of high-sensitivity detection reagents for trace skin sensitizers to improve the precision of skin sensitization tests : Evaluation using known sensitizers
Yohei Shimizu1), Masataka Kitadani1), Hideyuki Mizumachi2), Taku Nishijo2), Takuo Yuki2), Akihiro Moriuchi1), Ryo Koike1)
Alternatives to Animal Testing and Experimentation 27(suppl): 110-110, 2022.
English Article P-11. Useful ADRA fuorescence method to evaluate the skin sensitization potential of dyes
Kota Hatano, Nodoka Takahashi, Shiho Horiguchi, Honoka Iwasa, Nobuaki Nakamura
Alternatives to Animal Testing and Experimentation 27(suppl): 111-111, 2022.
English Article P-12. Development of machine learning model to predict human skin sensitization potential using chemical structure information
Jun Ito1), Kaori Ambe1), Takao Ashikaga2), Masahiro Tohkin1)
Alternatives to Animal Testing and Experimentation 27(suppl): 111-111, 2022.
English Article P-13. Evaluation and mechanistic analysis of adjuvant effect of nanomaterials using h-CLAT
Rion Arai1), Takao Ashikaga2), Akiko Ohno2), Kazutoshi Iijima3)
Alternatives to Animal Testing and Experimentation 27(suppl): 112-112, 2022.
English Article P-14. Exploring new index in the evaluation of nanomaterials to activate antigen-presenting cells using THP-1 cells
Kazutoshi Iijima1), Miho Suzuo2), Maki Yamashiro3), Akiko Ohno4), Takao Ashikaga4)
Alternatives to Animal Testing and Experimentation 27(suppl): 112-112, 2022.
English Article P-15. Ring study of ADRA, in chemico alternative test method for skin sensitization, aimed at revised guideline
Kazuya Takeuchi1), Kohei Kamiya1), Shinichi Watanabe2), Hiroaki Yamaga2), Koji Wakabayashi3), Yu Tahara3), Nobuyuki Horie4), Keiichi Fujimoto4), Tsuyoshi Kawakami5), Kohichi Kojima6), Takashi Sozu7), Hajime Kojima6)8), Yusuke Yamamoto9), Masaharu Fujita9), Toshihiko Kasahara9), Atsushi Ono10)
Alternatives to Animal Testing and Experimentation 27(suppl): 113-113, 2022.
English Article P-16. The applicability of ADRA in predicting skin sensitization by combining multiple alternative methods for the OECD DASS chemical set
Natsumi Nakashima1), Yusuke Yamamoto1), Sayaka Wanibuchi1), Hajime Kojima2)3), Atsushi Ono4), Kazuhiko Matsumoto5), Masaharu Fujita1), Toshihiko Kasahara1)
Alternatives to Animal Testing and Experimentation 27(suppl): 114-114, 2022.
English Article P-17. Assessment of commercial polymers with and without reactive groups using Amino acid Derivative Reactivity Assay (ADRA) based on both molar concentration approach and gravimetric approach
Sayaka Wanibuchi1), Masaharu Fujita1), Natsumi Nakashima1), Yusuke Yamamoto1), Hajime Kojima2)3), Atsushi Ono4), Toshihiko Kasahara1)
Alternatives to Animal Testing and Experimentation 27(suppl): 114-114, 2022.
English Article P-18. Skin-whitening ingredient Rhododendrol induces up-regulating of costimulatory molecule CD86 on dendritic cells through ROS generation and extrracellular ATP production in melanocytes
Yasuhiro Katahira, Eri Sakamoto, Yuma Furusaka, Aruma Watanabe, Ami Sekine, Miu Yamagishi, Jukito Sonoda, Hideaki Hasegawa, Izuru Mizoguchi, Takayuki Yoshimoto
Alternatives to Animal Testing and Experimentation 27(suppl): 115-115, 2022.
English Article P-19. Evaluation of craniofacial anomalies by detection of neural crest cells disruption
Shujie Liu1), Toru Kawanishi2), Atsuko Shimada2), Keita Yoshihara1), Takashi Ieki1), Naohiro Ikeda1), Hiroyuki Takeda2), Junichi Tasaki1)
Alternatives to Animal Testing and Experimentation 27(suppl): 115-115, 2022.
English Article P-20. Challenges to Compromise in Safety Evaluation on Cosmetics with Threshold of Toxicological Concern and Read-Across
Taisuke Kawamoto1), Anne Fuchs2), Rolf Fautz2), Osamu Morita1), Anne Zifle2), James Rathman3), Aleksandra Mostrag4), Chihae Yang4), Masaaki Miyazawa1)
Alternatives to Animal Testing and Experimentation 27(suppl): 116-116, 2022.
English Article P-21. Associations between repeated dose toxicity and in silico proflers or metabolic simulators used for chemical grouping
Michiko Watanabe, Yuki Sakuratani, Shino Kuwa, Ruriko Nakamura, Takeshi Morita, Yuko Obara
Alternatives to Animal Testing and Experimentation 27(suppl): 116-116, 2022.
English Article P-22. Construction of a bile canaliculus-like structure using sandwich-cultured cryopreserved human hepatocytes for predicting biliary excretion of food-derived compounds in vitro
Takashi Kitaguchi1), Shinichiro Horiuchi2), Yukie Kuroda2), Katsutoshi Ohno1), Kazuhiro Kobayash1), Mitsuru Tanaka1), Seiichi Ishida2)3)
Alternatives to Animal Testing and Experimentation 27(suppl): 117-117, 2022.
English Article P-23. Comparison of bile canaliculi formation between donors and improvement of biliary effux ability toward the development of in vitro biliary excretion assay
Shinichiro Horiuchi1), Yukie Kuroda1), Daiju Yamazaki1), Seiichi Ishida1)2)
Alternatives to Animal Testing and Experimentation 27(suppl): 117-117, 2022.
English Article P-24. Accuracy improvement of in silico transdermal absorption rate prediction model
Shinya Iwanaga1), Masaaki Mori1), Tomoka Hisaki1), Takumi Nukaga1), Hirokazu Kozuki2), Akiko Tamura1)
Alternatives to Animal Testing and Experimentation 27(suppl): 118-118, 2022.
English Article P-25. Development of a mathematical model for predicting percutaneous absorption of chemicals applied as fnite dose and the limitation of applicability of the mathematical model in the case of incorporating alternative skin membranes
Ryoki Kunita1), Takafumi Nishijima1), Masaaki Miyazawa2), Hiroaki Todo3), Kenji Sugibayashi4), Hitoshi Sakaguchi1)
Alternatives to Animal Testing and Experimentation 27(suppl): 118-118, 2022.
English Article P-26. Liver-small intestine drug metabolism-related crosstalk in vitro using on-chip perfused and direct oxygenated microphysiological system (MPS)
Kurniawan Dhimas1), Inamura Kousuke1), Danoy Mathieu1), Leo Sylvia2), Inamatsu Mutsumi3), Funaoka Sohei4), Aihara Daichi4), Sakura Takeshi4), Arakawa Hirosh5), Kato Yukio5), Matsugi Tomoaki1), Esashika Katsuhiro6), Nishikawa Masaki1), Shiraki Nobuaki2), Kume Shoen2), Kimura Hiroshi7)
Alternatives to Animal Testing and Experimentation 27(suppl): 119-119, 2022.
English Article P-27. Molecular pathological analysis of cancer cell clusters formed due to the loss of scaffold attachment
Kouhei Sakurai1), Akira Nagai2), Masaharu Akita3), Tatsuya Ando1), Yasuhiro Sakai1), Taku Kato1), Hiroyasu Ito1)
Alternatives to Animal Testing and Experimentation 27(suppl): 119-119, 2022.
English Article P-28. Evaluation for inhibitory effects of hybrid liposomes on the growth of breast cancer stem cells
Riko Jinno1), Yuji Komizu1), Hideaki Ichihara1), Yoko Matsumoto1), Taku Matsushita1), Seiichi Ishida1)2)
Alternatives to Animal Testing and Experimentation 27(suppl): 120-120, 2022.
English Article P-29. Statistical methods for binary-scale precision experiments and their international standardization
Jun-ichi Takeshita1), Tomomichi Suzuki2)
Alternatives to Animal Testing and Experimentation 27(suppl): 120-120, 2022.
English Article P-30. Construction and application of human cultured tissue with autonomic nervous system
Yuka Akagi1)2), Yuzo Takayama1), Yutaro Kumagai1), Yasuyuki S. Kida1)3)
Alternatives to Animal Testing and Experimentation 27(suppl): 121-121, 2022.
English Article P-31. Seesaw-driven in vitro intestinal model involving co-culture with E. coli
Naoya Ito, Junji Fukuda, Toshihiro Usui, Mioto Nishino
Alternatives to Animal Testing and Experimentation 27(suppl): 121-121, 2022.
English Article P-32. Development of iPS cardiomyocyte 3D micro tissues for cardiotoxicity by using the pin-type bioprinter
Shohei Chikae1)2), Yoshinari Tsukamoto1)2), Atsushi Oda1)2), Takuji Kobayashi2)
Alternatives to Animal Testing and Experimentation 27(suppl): 122-122, 2022.
English Article P-33. Development of 3D skin model that enables functional evaluation of cosmetic ingredients and skin care products
Katsunari Tezuka, Hiroaki Shichiri
Alternatives to Animal Testing and Experimentation 27(suppl): 122-122, 2022.
English Article P-34. 3D culture of human induced pluripotent stem cell-derived cardiomyocytes for cardiotoxicity assessment
Takeshi Sekiwa, Keiichiro Oiso, Junji Fukuda
Alternatives to Animal Testing and Experimentation 27(suppl): 123-123, 2022.
English Article P-35. Coculture of A549 cells and HepaRG cells on highly oxygen-permeable plates
Shinnosuke Chuman, Shinkichi Ishikawa
Alternatives to Animal Testing and Experimentation 27(suppl): 123-123, 2022.
English Article P-36. Functional maintenance of cultured hepatocytes by using E-cadherin coated plate
Rieko Tanaka, Kazuko Aizawa, Kazuaki Nakamura
Alternatives to Animal Testing and Experimentation 27(suppl): 124-124, 2022.
English Article P-37. Compartmentalized three-dimensional human neuromuscular tissue models for in vitro analysis of neuromuscular diseases
Yuhei Kamei, Ayumu Matsushima, Kazuki Yamamoto, Hirokazu Akiyama, Hiroyuki Honda, Kazunori Shimizu
Alternatives to Animal Testing and Experimentation 27(suppl): 124-124, 2022.
English Article P-38. In silico model for predicting skin permeation of substances after its fnite dose application
Ibuki Narita1), Chihiro Fujiwara1), Shouko Itakura1), Kenji Sugibayashi2), Hiroaki Todo1)
Alternatives to Animal Testing and Experimentation 27(suppl): 125-125, 2022.
English Article P-39. Assessing the impact of dataset partitioning on the performance of machine learning to predict chemical toxicity
Tadahaya Mizuno, Katsuhisa Morita, Hiroyuki Kusuhara
Alternatives to Animal Testing and Experimentation 27(suppl): 125-125, 2022.
English Article P-40. In silico approach that supports neurotoxicity assessment of chemical substances by IATA : Refning categories by using substructures and physicochemical and biochemical parameters related to neurotoxicity
Takashi Yamada, Shinji Tsujii, Minoru Miura, Akiko Saito, Tomoko Kawamura, Taeko Maruyama, Naruo Katsutani, Akihiko Hirose
Alternatives to Animal Testing and Experimentation 27(suppl): 126-126, 2022.
English Article P-41. Development of a machine learning model to improve effciency of in vitro assays for skin sensitization assessment
Kei Kinoshita1), Kaori Ambe1), Takao Ashikaga2), Masahiro Tohkin1)
Alternatives to Animal Testing and Experimentation 27(suppl): 126-126, 2022.
English Article P-42. Development of a read-across method for evaluating repeated-dose toxicity using molecular descriptors : Examination of methods of selecting molecular descriptors for better prediction
Yu Harakawa1), Nao Omura1), Jun-ichi Takeshita1)2), Ryota Shizu1), Takuomi Hosaka1), Yuichiro Kanno1), Kouichi Yoshinari1)
Alternatives to Animal Testing and Experimentation 27(suppl): 127-127, 2022.
English Article P-43. Development of an in silico model for the liver homeostasis breakdown and fbrosis
Masaki Nishikawa1), Misa Yoshizawa2), Masahiro Sugimoto3), Minoru Tanaka4), Yasuyuki Sakai1)
Alternatives to Animal Testing and Experimentation 27(suppl): 127-127, 2022.
English Article P-44. Investigation of read-across methods for predicting developmental neurotoxicity
Nao Omura, Ryota Shizu, Takuomi Hosaka, Yuichiro Kanno, Kouichi Yoshinari
Alternatives to Animal Testing and Experimentation 27(suppl): 128-128, 2022.
English Article P-45. Construction of a layered 3D co-culture model as an alternative method for animal experiments in drug evaluation
Yuma Yokokawa1)2), Yuki Takahashi1)2), Shiro Kitano1), Eiji Shinozaki3), Ryohei Katayama2)4), Naoya Fujita2)
Alternatives to Animal Testing and Experimentation 27(suppl): 128-128, 2022.
English Article P-46. Anti-cancer drug screening with a unique layered 3D co-culture model
Yuki Takahashi1)2), Yuma Yokokawa1)2), Shiro Kitano1), Eiji Shinozaki3), Ryohei Katayama2)4), Naoya Fujita2)
Alternatives to Animal Testing and Experimentation 27(suppl): 129-129, 2022.
English Article P-47. Electrochemical analysis of intestinal models
Chisato Ito1), Kosuke Ino2), Kazuyuki Iwase3), Itaru Honma3), Hitoshi Shiku1)2)
Alternatives to Animal Testing and Experimentation 27(suppl): 129-129, 2022.
English Article P-48. Construction of a screening system for assessing contractile force of in vitro human skeletal muscle atrophy models
Kazunori Shimizu, Hirokazu Akiyama, Hiroyuki Honda
Alternatives to Animal Testing and Experimentation 27(suppl): 130-130, 2022.
English Article P-49. A novel system for air-liquid interface exposure of PM2.5 to human 3dimensional cultured epidermal model
Maori Kono1)2), Masayuki Takaishi1)2), Kazuhiko Kinoshita1), Hidefumi Ikeda1)2), Tomoaki Okuda3), Yasuhiro Ishihra4)
Alternatives to Animal Testing and Experimentation 27(suppl): 130-130, 2022.
English Article P-50. A rapid OCT-based approach for vessel quantifcation of 3D blood-brain barrier model
Huiting Zhang1)2), Noriyuki Nakatani3), Daisuke Tominaga4), Marie Piantino2), Dong Hee Kang2), Tomomi Furihata5), Michiya Matsuzaki1)2), Satoshi Fujita1)2)
Alternatives to Animal Testing and Experimentation 27(suppl): 131-131, 2022.
English Article P-51. Development of a new test method using Japanese quail embryos to detect chemical-induced abnormalities in sexual differentiation
Takaharu Kawashima1), Win Shwe Tin Tin1), Asato Kuroiwa2), Shusei Mizushima2), Shinji Tsukahara3)
Alternatives to Animal Testing and Experimentation 27(suppl): 131-131, 2022.
English Article P-52. Importance of glial cells in assessing neurotoxicity : a basic study using mouse-derived strain cells
Masahiro Ohgidani, Eriko Furube, Shigetaka Yoshida
Alternatives to Animal Testing and Experimentation 27(suppl): 132-132, 2022.
English Article P-53. Real-time luminescence monitoring of signal disruption to evaluate the developmental toxicity for pharmaceuticals
Yusuke Okubo1), Kashu Mizota1)2), Satoshi Kitajima1), Yoko Hirabayashi3), Yoshihiro Nakajima4), Junji Fukuda4)
Alternatives to Animal Testing and Experimentation 27(suppl): 132-132, 2022.
English Article P-54. Evaluation of the immunotoxicity of nanoparticles of cerium dioxide and zinc oxide using THP-1 cells
Maki Yamashiro1), Takao Ashikaga2), Akiko Ohno2), Kazutoshi Iijima3)
Alternatives to Animal Testing and Experimentation 27(suppl): 133-133, 2022.
English Article P-55. Development of a supercooling preservation method of adherent cultured cells
Maaya Hikichi
Alternatives to Animal Testing and Experimentation 27(suppl): 133-133, 2022.
English Article P-56. Co-culture of renal tubular cells and endothelial cells and the effect of fbroblasts for the development of a three-dimensional tubular model
Miyuu Yamazaki
Alternatives to Animal Testing and Experimentation 27(suppl): 134-134, 2022.
English Article P-57. In vitro evaluation of drug-induced kidney injury by three-dimensional culture of proximal tubular epithelial cells
Hiroshi Arakawa1), Daichi Higuchi1), Etsushi Takahashi2), Shiho Nedachi1), Masayuki Kondo2), Yoichi Jimbo2), Ikumi Tama1)
Alternatives to Animal Testing and Experimentation 27(suppl): 134-134, 2022.
English Article P-58. Development of 3D-culture model using human renal proximal tubule epithelial cells and characterization of its transporter function
Etsushi Takahashi1), Fumihiko Kitagawa1), Masayuki Kondo1), Asami Saito2), Gaku Morinaga2), Masahito Takatani2), Naoki Ishiguro2), Hiroshi Arakawa3), Daichi Higuchi3), Shiho Nedachi3), Ikumi Tamai3), Yoichi Jimb1)
Alternatives to Animal Testing and Experimentation 27(suppl): 135-135, 2022.
English Article P-59. Development of evaluation system for effects on the central nervous system of food ingredients using human iPS cell-derived neural progenitor cells
Yuki Hanafusa1), Fumiyuki Hattori2)
Alternatives to Animal Testing and Experimentation 27(suppl): 135-135, 2022.
English Article P-60. Development of a novel MAT test using immortalized myeloid cells (aMylc) derived from human PBMCs
Toshie Kusunoki, Ami Murakami, Yuka Yoshimura, Yua Yoshimura, Sachiko Maeno, Jun Shimizu, Kazuo Miyazaki
Alternatives to Animal Testing and Experimentation 27(suppl): 136-136, 2022.
English Article P-61. Electrophysiological drug assessment of human iPSC-derived sensory neurons using Multi-Electrode Array (MEA) and their potential as an alternative model for dorsal root ganglia
Minami Hiranuma, Yuichi Okuda, Tomohisa Watanabe
Alternatives to Animal Testing and Experimentation 27(suppl): 136-136, 2022.
English Article P-62. Investigation of non-invasive evaluation by toxicity assay using spheroids
Asako Motomura1), Yoko Igarashi1), Hiroshi Suganuma1), Yoshihiko Watanabe2), Kazuya Matsushima2), Nobuhiko Kojima2)
Alternatives to Animal Testing and Experimentation 27(suppl): 137-137, 2022.
English Article P-63. An on-chip pump integrated multi-organ microphysiological system for drug development
Kenta Shinha1), Hiroko Nakamura1), Naoki Ishida2), Hiroshi Arakawa2), Masaki Nishikawa3), Yukio Kato2), Yasuyuki Sakai3), Hiroshi Kimura1)
Alternatives to Animal Testing and Experimentation 27(suppl): 137-137, 2022.
English Article P-64. Research contributing to the development of a bile excretion evaluation system using 3D culture scaffold, Cellbed by mimicking the in vivo bile excretion function from hepatocytes
Ryota Oyafuso1), Yuji Komizu1), Takuya Iwasa2), Kouhei Sasaki2), Rie Kojima2), Masaaki Kawabe2), Taku Matsushita1), Seiichi Ishida1)3)
Alternatives to Animal Testing and Experimentation 27(suppl): 138-138, 2022.
English Article P-65. In-vitro electrophysiological evaluation of pancreatic β cells based on thin flm transistor microelectrode arrays
Dongchen Zhu1), Anne Claire Eiler4), Satoshi Ihida2), Yasuyuki Sakai1), Hiroshi Toshiyoshi2), Agnes Tixier Mita2), Kikuo Komori3)
Alternatives to Animal Testing and Experimentation 27(suppl): 138-138, 2022.
English Article P-66. Improvement of similarity to blood vessels and infammatory response of HUVECs by spheroid culture
Daiki Tanaka, Sanshiro Hanada, Nobuhiko Kojima
Alternatives to Animal Testing and Experimentation 27(suppl): 139-139, 2022.
English Article P-67. Use of silkworm strains as alternative experimental animals for the evaluation of functions to improve metabolic syndrome
Ryuichiro Tanaka1), Ryouhei Mori1), Eisuke Miyazaki1), Sayaka Tanibuchi1), Kai Motoki1), Yutaka Banno2)
Alternatives to Animal Testing and Experimentation 27(suppl): 139-139, 2022.
English Article P-68. 3D tumor device with perfusable blood vessels
Nobuhito Mori1), Ryo Tsumura2), Yoshikatsu Koga3), Yasuyuki S. Kida1)3)
Alternatives to Animal Testing and Experimentation 27(suppl): 140-140, 2022.
English Article P-69. Reproduction of drug resistance in human pancreatic cancer cells using three-dimensional culture carrier
Yuji Komizu1), Seiichiro Chitose1), Kouhei Hiyoshi1), Mayuko Kitajima1), Takuya Iwasa2), Kouhei Sasaki2), Rie Kojima2), Masaaki Kawabe2), Taku Matsushita1), Seiichi Ishida1)3)
Alternatives to Animal Testing and Experimentation 27(suppl): 140-140, 2022.
English Article P-70. Deactivation of hepatic stellate cells in three-dimensional culture for the culture technique for therapeutic drug development for non-alcoholic steatohepatitis (NASH)
Satoha Aihoshi1), Yukie Kuroda2), Shinichiro Horiuchi2), Hiroyoshi Sadohara1), Riko Jinno1), Yuji Komizu1), Taku Matsushita1), Seiichi Ishida1)2)
Alternatives to Animal Testing and Experimentation 27(suppl): 141-141, 2022.
English Article P-71. Toward the Development of Qualitative and Quantitative Analytical Devices for On-site Rapid Evaluation of Biomacromolecules in Cell-based Bioassays
Kikuo Komori1), Dongchen Zhu2), Ayano Takenouchi1), Yuma Hori1), Satoshi Ihida2), Yasuyuki Sakai2), Hiroshi Tioshiyoshi2), Hiroshi Kimura3), Agnes Tixier Mita2)
Alternatives to Animal Testing and Experimentation 27(suppl): 141-141, 2022.
English Article P-72. Development of an Integrated Aerobic Cell Culture System with a Glucose Sensor
Yuma Hori1), Hiroshi Kimura2), Kikuo Komori1)2)
Alternatives to Animal Testing and Experimentation 27(suppl): 142-142, 2022.
English Article P-73. Development of 2D and 3D Functional Platforms for Integrated Neuromuscular Junction Studies
Margaret Anne Craig, Ashley Barnes
Alternatives to Animal Testing and Experimentation 27(suppl): 142-142, 2022.
English Article P-74. Introduction of 3rd Asian Congress for Alternatives to Animal Experiments (ACAAE) organized by Korean Society for Alternatives to Animal Experiments (KSAAE)
Ki-Suk Kim1)2)
Alternatives to Animal Testing and Experimentation 27(suppl): 143-143, 2022.
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